组织介绍

CADD

MAT2A : 正构和别构抑制剂。以下为别构，7KCC(AG-270)参考文献, 7KCE, 7KCF, 7KDA, 7KDB

CBL-B : 什么是CBL—B, Human Casitas B-lineage lymphoma proto-oncogene b (CBL-B) is an E3 ubiquitin-protein ligase that functions as a negative regulator of T-cell activation.

泛素与肿瘤. )

Tripeptide GpYM binds the Cbl-b TKB domain and inhibits IRS-1 ubiquitination 三肽抑制剂和CBL- B TKB domain的晶体
泛素蛋白链接酶B

NX-1607，非PROTACS， Liganse inhibition

NX公司，PRORTACS相关阅读

GLP-1分子Smiles
PF06882961（阳性药）：
N#Cc1cc(F)c(cc1)COc(n2)cccc2C3CCN+Cc(n4CC5CCO5)nc(c46)ccc(C([O-])=O)c6

AI设计（第三次提交）：
O=C2N(CCCC(=O)NCCOC)C(=O)C1=CC(OC)=C(C=C1N2CC(=O)N/C3=C/C([F])=C(C)C=C3)OC
O=[S]1(=O)CC@@([H])C(=O)N1/C2=C/C([Cl])=C(C=C2)C(=O)NCCC=3C=CC(=CC=3)S(=O)N
O=C(/C1=N/OC(C)=C1CN2/N=C(/C)C(C)=C2C)N3CCCC[C@@]3([H])C=4N=C(ON=4)COC=5C=CC(C)=CC=5
[O-]N+C=1C=C(C=CC=1)C2=NN=C3N2C(=NC=4C=CC(C)=CC3=4)N5CCCC5
[O-]N+C=1C=CC=C2C=1C=CN2CC(=O)NC@([H])C3=NN=C4C=CC=CN34
COc1cc(Cn2c(C)nc3c2cccc3)c(cc1Cn1c(C)nc2c1cccc2)OC
COc1ccc(cc1C(=O)N1CCCCC1)/N=c/1[nH]nc(c2c1cccc2)c1ccc(c(c1)S(=O)(=O)N1CCCCC1)C
OC(=O)CCC(C(=O)O)NC(=O)c1ccc(cc1)N(Cc1cnc2c(n1)c(N)nc(n2)N)C
c1(c[nH]c2c1cccc2)CN1CC@HCC@@HCOc1cc2c(cc1)CCC2